Researchers in academia and life science industries continue to adopt a targeted, bottom-up MS-based proteomic workflow for biomarker discovery and validation. Biomarker validation requires absolute quantification of surrogate peptides in the sample matrix, a requirement that is best achieved using stable isotope-enriched peptide internal standards (SIS). Although the use of SIS has increased the reliability of LC-MRM/MS-based assays, optimal results require properly functioning equipment and a workflow with minimal human error and bias.

To help researchers establish a stable LC-MRM/MS platform for bottom-up quantitative proteomics, Cambridge Isotope Laboratories, Inc. is pleased to offer PeptiQuant™ kits from MRM Proteomics Inc. These kits include the PeptiQuant™ Monthly LC-MS Platform Performance Kit, the PeptiQuant™ Daily LC-MS Platform Performance Kit, and the PeptiQuant™ Workflow Performance Kit. These innovative products are used to assess and track LC-MS performance of the LC-MS platform in a proteomic workflow in order to highlight any possible issues affecting quantitation.